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KMID : 0363319980190020317
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Journal of Korean Oriental Internal Medicine
1998 Volume.19 No. 2 p.317 ~ p.332
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A study on the effects of Poria extract on rat with nephrotoxicity induced by Cyclosporin A
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Jew Jae-Hong
Kim Dong-Woo
Han Yang-Hee
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Abstract
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The purpose of this study is to find out the effects of Poria extract on rat’s nephrotoxicity induced by CsA. The experimental animals were divided into 3 groups and treated as follows; Nothing was given to Sample A, Sample B was given normal saline after IV injection of CsA and Sample C was given Poria extract after CsA injection. After precription of medicine, serum BUN, creatinine, total protein, sodium, potassium, chloride ions were measured.
1. Changes in serum level. ALT, BUN, chloride ion were significantly reduced in experimental group as compaired to control group, and total protein showed significant elevation in experimental group. AST was reduced, but not significant and creatine level was below the normal range. K level showed mild elevation initially and later showed mild decrease, but no significance is noted. There were no significant differance in the sodium level.
2. Changes in Urine level. Urinary specific gravity showed significant increase in experimental group compaired to control group. Urinary creatinine level initially increased, and later decreased but showed no significance.
To conclude, it can be inferred that Poria may improve nephrotoxicity and hepatotoxicity in rat induced by Cyclosporin A.
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KEYWORD
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CsA, Poria, K, AST, ALT, BUN, Creatinine, Total protein, Sodium, Potassium
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